Spike SARS CoV-2 (E484K; N501Y) mRNAs have been designed to produce high expression level of spike protein.
OZB ExploCap mRNAs are produced by in vitro transcription and are co-transcriptionally capped using trinucleotides ExploCap analog. mRNAs also contain stabilizing untranslated region (UTRs) and a poly(A) tail at the 3’ end. Sequences have been optimized to yield improved stability and performance.
ExploCap Spike SARS CoV-2 mRNA:
#MRNA116 does not bear any additional chemical modifications.
#MRNA117 is modified with 5-methoxyuridine (5moU).
#MRNA118 is modified with N1-methyl-pseudouridine (N1-mψ) to reduce innate immune response.
- Cap Modification: ExploCap™
- Poly (A) Tail: Yes
- Concentration: 1.0 mg/mL
- Buffer: 1 mM Sodium Citrate, pH 6.4
- Full length mRNA: 4036 nt
- Size: 20 µg, 100µg and 1 mg
- Storage: -80°C
- Shipping: Dry ice (fee included in shipping cost)
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